COVID Vaccine: What does it do? Does it do anything? Let’s find out.

I made a video going over some of the basic biochemistry of the SARS-CoV-2 virus and how the Pfizer/BioNTech BNT162b2 RNA vaccine is supposed to work.

Resources and References:

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates


Guidelines on clinical evaluation of vaccines: regulatory expectations


Decoding the SARS-CoV-2 Genomes – Origin


Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak


Genomic variance of the 2019-nCoV coronavirus


The Human Coronavirus Disease COVID-19: Its Origin, Characteristics, and Insights into Potential Drugs and Its Mechanisms


Humanized mice develop coronavirus respiratory disease


Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS-CoV-2


Crystal structure of SARS-CoV-2 papain-like protease


Distinct conformational states of SARS-CoV-2 spike protein


Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases


Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein


Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2


Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?


A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells


TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells


mRNA vaccines — a new era in vaccinology


The promise of mRNA vaccines: a biotech and industrial perspective


Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections


Peripheral Blood Mononuclear Cells: A Brief Review


PDB Codes:

6VXX – SARS-CoV-2 Spike Protein (pre-fusion conformation)

6VYB – SARS-CoV-2 Spike Protein (pre-fusion conformation)

6VW1 – SARS-CoV-2 Spike Protein (pre-fusion conformation)

6ACK – SARS-CoV Spike Protein + Human ACE2

6XRA – SARS-CoV-2 Spike Protein (post-fusion conformation)

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