COVID Vaccine: What does it do? Does it do anything? Let’s find out.

I made a video going over some of the basic biochemistry of the SARS-CoV-2 virus and how the Pfizer/BioNTech BNT162b2 RNA vaccine is supposed to work.

Resources and References:

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

Guidelines on clinical evaluation of vaccines: regulatory expectations

Decoding the SARS-CoV-2 Genomes – Origin

Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

Genomic variance of the 2019-nCoV coronavirus

The Human Coronavirus Disease COVID-19: Its Origin, Characteristics, and Insights into Potential Drugs and Its Mechanisms

Humanized mice develop coronavirus respiratory disease

Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS-CoV-2

Crystal structure of SARS-CoV-2 papain-like protease

Distinct conformational states of SARS-CoV-2 spike protein

Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2

Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

mRNA vaccines — a new era in vaccinology

The promise of mRNA vaccines: a biotech and industrial perspective

Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections

Peripheral Blood Mononuclear Cells: A Brief Review

PDB Codes:

6VXX – SARS-CoV-2 Spike Protein (pre-fusion conformation)

6VYB – SARS-CoV-2 Spike Protein (pre-fusion conformation)

6VW1 – SARS-CoV-2 Spike Protein (pre-fusion conformation)

6ACK – SARS-CoV Spike Protein + Human ACE2

6XRA – SARS-CoV-2 Spike Protein (post-fusion conformation)