Cartesian dualism has been a point of contention in philosophy since at least, well, Descartes. The dispute is whether the mind is a separate, immaterial entity from the physical body. Problems have plagued the dualist view since the time of Descartes, primarily how it is that the immaterial mind and material body interact.
Human nature, as I define it, is the set of cognitive and behavioral patterns that are innate in human beings, regardless of culture and specific upbringing. These are patterns passed down to us by evolution. With humans, though, we seem to be unique in our ability for metacognition – thinking about our thinking and our behaviors. Does that give us the ability to change our innate human nature?